Erectile Dysfunction Medications
Erectile dysfunction medications
The problems in sexual life are not new nowadays. Every third man had at least once in his life some problems with conducting a sexual intercourse. It can have different causes and must be treated to prevent severe consequences.
For many centuries, in order to prolong sexual longevity, were using various stimulants, mainly of plant origin; many of them belonged to stimulators and had hallucinogenic, psycho-stimulant and other properties.
The main factors influencing the occurrence of an erection:
- relaxation of smooth muscles;
- hemodynamic changes;
- regulatory action of neurotransmitters;
To the causes of ED belong age, diabetes mellitus, smoking, atherosclerosis, side effects of drugs, cardiovascular diseases, prostatic diseases, spinal cord injury, depression etc. To the ED-occurrence may contribute a drug therapy, for example diuretics of thiazide series, non-selective beta-blockers, sympatholytic etc.
Among the drugs for ED-treatment one can distinguish the following groups:
- 1. medications that increase levels of nitric oxide:
- selective PDE5 inhibitors: Sildenafil citrate, Tadalafil 20mg, Vardenafil;
- activators of NO-synthase;
- 2. alpha-blockers:
- selective alpha2-adrenoceptor antagonists;
- non-selective alpha blockers;
- 3. analogues of prostaglandin E;
- 4. medications a complex composition;
- 5. androgens: testosterone;
- 6. myotropic antispasmodics;
Numerous clinical studies have proven the efficacy and safety of PDE5 inhibitors for the treatment of ED. These drugs differ in duration: Sildenafil citrate 100mg and Vardenafil are up to 5 hours, Tadalafil - up to 36 hours. The effect is manifested only during sexual arousal. Long-term efficacy of Tadalafil can restore spontaneity and naturalness of sexual relations. Sildenafil citrate and Vardenafil 20mg are similar in chemical structure while Tadalafil substantially differs from them in structure and pharmacokinetic properties.
For the treatment of ED is also used a variety of medications of natural origin, such as laveron, Tentex forte, testalamin or erektin. The interest to the techniques of so-called biological medicine in the world is great. This is due to the fact that these drugs have significantly fewer side effects in comparison with the chemotherapeutic drugs and do not cause addiction or withdrawal. Many of them aren't medicines and are referred to biologically active additives.